What is Glucosamine?
Glucosamine is made up of glucose and glutamine, substances used naturally by the body to keep cartilage moist and pliant. Glucosamine plays a vital role in the structuring of healthy bone, cartilage, and other tissues. Glucosamine is also one of the nutrients that form the cushioning ingredients in the fluids of the joints and surrounding tissues. The compound is extracted from crab, lobster or shrimp shells.

What is Chondroitin Sulfate?
Chondroitin sulfate is part of a large protein molecule (proteoglycan) that gives cartilage elasticity, and occurs naturally in the human body. Loss of this compound in arthritis causes deterioration of joint cartilage leading to stiffness, pain and inflamation. Chondroitin sulfate is made from animal cartilage, such as tracheas or shark cartilage.

What is CMO - (cis-9-cetylmyristoleate)?
The effect of cetylmyristoleate on joints was discovered by U.S.National Institutes of Health chemist H. W. Diehl and an article describing its discovery was published in Journal of Pharmaceutical Sciences [83(3):296-298]. It works as an immuno-modulator serving to repair the body's auto-immune disorder which is the common cause of arthritis. The active ingredients in CMO are wholly derived from 100% natural bovine food sources. When used for joint support, in a randomized clinical trial, cetyl myristoleate achieved an astounding 87.3% response when taken with glucosamine and hydrolyzed cartilage (as formulated in ArthritiCare).

What is Arthiti-Care?
Arthiti-Care is a uniquely formulated safe and effective cream for treatment of both inflammation as well as cartilage repair in the case of Osteoarthritis and Rheumatoid arthritis. Its main ingredients are Glucosamine, Chondroitin Sulfate and CMO (a cartilage replacement compound) - delivered transdermally to the joints. Together they form an extremely effective therapy.
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Glucosamine and Chondroitin Sulfate - Clinical Studies:
"An analysis of clinical trials on glucosamine and chondroitin sulfate for treating osteoarthritis has shown that these compounds may have some efficacy against the symptoms of this form of arthritis.
The study, by Timothy E. McAlindon, DM, and colleagues at the Boston University School of Medicine, located 37 studies of the compounds in osteoarthritis by a thorough review of the scientific literature published over more than three decades.
Based on data from the trials, the researchers calculated an overall "effect size" for the two compounds: the figure 0.2 is considered a small effect; 0.5, moderate; and 0.8, large. The researchers calculated an effect size for glucosamine of 0.44 and for chondroitin sulfate of 0.78..."**
** The study was published in the March 15, 2000, issue of the Journal of the American Medical Association (JAMA).

Glucosamine and chondroitin sulfates in the treatment of osteoarthritis:
Survey de los Reyes GC, Koda RT, Lien EJ. Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.

For more than 30 years, non-steroidal anti-inflammatory drugs (NSAIDs) have been used as standards in the treatment of osteoarthritis (OA). Serious and often life-threatening adverse effects due to these agents are common. Clinical findings have revealed that glucosamine sulfate and chondroitin sulfate are effective and safer alternatives to alleviate symptoms of OA. Experimental evidence indicates that these compounds and their low molecular weight derivatives have a particular tropism for cartilage where they serve as substrates in the biosynthesis of component building blocks. This paper is a literature review of the chemistry, mechanism of action, pharmacokinetics, clinical efficacy and safety of these two nutraceuticals.
Publication Types: Review, Tutorial PMID: 11127967 [PubMed - indexed for MEDLINE]

CMO (cetylmyristoleate) Clinical Results:

Below are extracts from San Diego Clinic Immunological Center Clinical Study On Cetylmyristoleate (CMO) vs Arthritis - both Osteo and Rheumatoid Arthritis:

• Dosage level requirements appear to be equal irrespective of the severity of the subjects condition.
• The time for maximum attainable response appears to vary from seven to twenty one days, resulting in 70% to 100% overall improvement.
  (Click for complete study)
  Click here to learn more about Transdermal drug delivery.